doi: 10.1007/s11427-015-4853-0 119 KowluruR
213,214 The accumulation of ROS in the cell leads to unfolded protein response and induces endoplasmic reticulum stress
Knee Swelling Excess fluid builds up in or around the knee joint causing the knee to appear larger, feel stiff, and sometimes lead to pain and reduced mobility
This indicates that the metabolic remodeling effect of MA is conserved across species
But none of this shows visibly yet
Thank you to our sponsors AG1 (Athletic Greens): Thesis: InsideTracker: Helix Sleep: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality (00:02:51) Momentous Supplements (00:03:46) Thesis, InsideTracker, Helix Sleep (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The 4 Horseman of Disease (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States (00:13:59) Blood Testing: Best Frequency (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your Marginal Decade (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max (00:44:43) Attias Rule of Supplementation, Centenarian Decathlete Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin (01:52:06) Testosterone Replacement Therapy & Fertility (01:59:26) Total Testosterone vs
